If you have Steam Cloud enabled and there is a problem with your save games, this solution often resolves the issue. 

How to resync save games

  • Exit and re-open Steam
  • Open Steam to the Game Library
  • Right/Cmd click on Shadowrun: Dragonfall Director's Cut
  • Click on “Properties”
  • Select the “Updates” tab
  • Make sure the "Enable Steam Cloud" checkbox is checked.
  • Navigate to your Shadowrun: Dragonfall Director's Cut save game location (http://shadowrun-returns.wikispaces.com/Game+File+Locations+by+OS)
  • Move all of your save game files OUT of the "...\remote\saves" folder and to a different folder (for backup purposes.)
  • Fully quit and then restart Steam, and wait for Shadowrun: Dragonfall Director's Cut to finish syncing. This should re-sync all of your save game files from Steam cloud. 
  • Load your save game and then immediately use "Restart Level" from the PDA menu.